| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2b5005b473b73e158899328dd7e6331
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f600c9ee4c6540d4a82ad41cdf3eb21b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2021-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30cc2eeff44ce1841dfff61fb12b4412
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f8e418473d5bfde1ebc7cd2c38d916d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7fb0077cdaf320d2578d963b59933f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_343751523d8afe8caee23a51124908ef |
| publicationDate |
2022-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-115215939-A |
| titleOfInvention |
A kind of fusion protein and its preparation method and application |
| abstract |
The invention belongs to the field of biomedicine and discloses a fusion protein and a preparation method and application thereof. The fusion protein comprises a polypeptide that specifically binds to KRas protein, a tumor cell-specific transmembrane peptide and a lysosome recognition peptide. For the first time, the present invention designs and constructs a fusion protein with tumor targeting and penetrating properties and protein-specific degradation aiming at the "non-drugable" protein, which provides a new idea for the development of anti-cancer targeting drugs; the fusion protein is different from the existing There is technology that a molecule can only target one target protein, which can induce the degradation of wild-type and mutant KRas proteins at the same time; at the same time, the fusion protein can increase the sensitivity of KRas mutant tumors to tumor-targeted drugs by inducing KRas degradation Therefore, it is of great significance in the clinical treatment of tumors to expand the scope of application of existing anti-cancer targeted drugs. |
| priorityDate |
2021-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |