| abstract |
The invention relates to the technical field of medical materials, and specifically discloses a bone repair bracket with a gradient coating and a preparation method thereof. The bone repair scaffold comprises a porous ceramic matrix and a polymer coating on the surface thereof, wherein the polymer coating is loaded with trace elements in a gradient concentration manner, wherein the trace elements are selected from magnesium, zinc, copper, calcium, strontium, and iron. one or more. In the present invention, the multi-layer polymer coating is applied on the basis of the porous ceramic stent, so that the strength and toughness of the porous ceramic stent are improved, and the polymer coating has a certain swelling after implantation, which can stabilize the stent. effect. Among them, trace elements with special functions are doped in the polymer coating in the form of ion crosslinking. Further, the concentration of trace elements is controlled in the form of multi-layer coating to change gradient from the outer layer of the coating to the inner layer, so that different concentrations or different types of trace elements can be released in different periods after stent implantation to meet the actual needs of the human body. . |