| abstract |
This application relates to the fields of virology and immunology. In particular, the present application relates to a receptor binding domain (RBD) mutant of the S protein and uses thereof. In addition, the present application also relates to pharmaceutical compositions (eg vaccines) comprising said mutants, and methods of preparing said mutants. The application provides a mutant of the RBD of the S protein, which can induce protective antibodies against different coronaviruses (for example, SARS-CoV-2, SARS-CoV-1), and achieve anti-coronaviruses of different subtypes. Protective effects. |