| abstract |
The invention relates to the field of biotechnology, in particular to the intestinal flora related to the curative effect of cancer treatment and its application. The present invention provides intestinal flora related to the therapeutic efficacy of cancer, including the following five intestinal microorganisms: Rothia, Bacteroides, Ruminococcus, Subdoligranulum and Christensenellaceae_R_7_group. In a second aspect, the present invention provides the use of a detection reagent in the preparation of a kit for predicting the efficacy of cancer treatment, the detection reagent is used to detect the presence and abundance of five intestinal microorganisms including Rothia, Bacteroides, Ruminococcus, Subdoligranulum and Christensenellaceae_R_7_group. degree information; predicting patient response to cancer treatment through the presence and abundance of gut microbes. The advantages of the present invention are: (1) non-invasive, high efficiency and low cost. (2) The curative effect prediction effect is good. (3) Additional treatments can be provided to maximize clinical benefit for patients. |