| abstract |
C4'-trifluoromethylthio-modified nucleosides and preparation methods of C4'-trifluoromethylthio-modified nucleic acids, discloses C4'-trifluoromethylthio-substituted deoxythymidine [formula (1)], C4'-trifluoromethylthio Fluoromethylthio substituted deoxythymidine phosphoramidite monomer [formula (2)], C4'-trifluoromethylthio substituted deoxythymidine modified DNA, C4'-trifluoromethylthio substituted uridine [formula ( 3)], C4'-trifluoromethylthio substituted uridine phosphoramidite monomer [formula (4)], C4'-trifluoromethylthiouridine modified RNA preparation method. In formula (2) and (4), "DMTr-" is dimethoxytrityl; in formula (4), "R 1 " is methyl or nitrile ethyl, and " R 2 " is ethyl or isopropyl Base, "TBDMS" is tert-butyldimethylsilyl chloride. These C4'-trifluoromethylthio substituted nucleosides and nucleic acids have broad application prospects in the research of structure and function of nucleoside drugs and nucleic acids. |