| abstract |
The invention belongs to the technical field of organic synthesis, and in particular relates to a preparation method of a sulfoxide compound containing an indole skeleton. β-Sulfinyl tert-butyl ester (compound I) and N-(o-iodophenyl) allenamide (compound II) react in one step under the catalytic system of alkali, palladium catalyst and phosphine ligand to prepare indole skeleton-containing Sulfoxide compounds. In the preparation method of the indole skeleton-containing sulfoxide compound provided by the present invention, the raw material compound I and compound II can be prepared by a simple method, and at the same time, the reaction conditions are mild, the substrate expansion range is wide, and the preparation operation is simple. |