| abstract |
Disclosed are compositions, vectors and methods for treating and preventing rabies virus infection, including rabies virus encephalitis, in a subject in need thereof. The disclosed compositions relate to anti-rabies immunoglobulins and vectors for expressing anti-rabies immunoglobulins in a subject in need thereof, such as adeno-associated virus (AAV) vectors expressing anti-rabies immunoglobulins. In some embodiments, the disclosed methods relate to treating and/or preventing rabies infection in a subject in need thereof, the methods comprising administering to the subject a dose of an adeno-associated virus (AAV) vector, The AAV vector expresses immunoglobulins that bind to and neutralize rabies virus in the subject. |