http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115166104-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 |
| filingDate | 2022-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-115166104-B |
| titleOfInvention | Method and application for separating pitavastatin calcium starting material and its impurities |
| abstract | The invention discloses a method and application for separating pitavastatin calcium starting material and its impurities. The method of the present invention comprises the steps of: adopting liquid chromatography to separate the pitavastatin calcium starting material and impurities in the solution; the chromatographic column used is a C4-T chromatographic column, which is buffered with mixed acid-triethylamine Liquid was mobile phase A, tetrahydrofuran was mobile phase B, and methanol was mobile phase C. Gradient elution was performed. The pH of mobile phase A was 2.9-3.7. The present invention is by selecting suitable mobile phase, and controlling conditions such as the buffer salt ratio of mobile phase and flow rate, chromatographic column, column temperature, detection wavelength, especially by selecting suitable chromatographic column, controlling the pH value of mobile phase and gradient elution procedures, so that the starting material and its three impurities can be effectively separated under the same detection method, and the detection sensitivity is high, the specificity is good, and the accuracy is high. |
| priorityDate | 2022-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.