http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115160429-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dbc6e2326cc7184ea0c01c9e41e57b47 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-605 |
| filingDate | 2021-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e11156e86819028ce8fa3679352cfab4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49e5f8d7424707064edc60ca8b86127d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b3205bc3043268e5d6cb9ebd2f8f3c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f21c447b930c6263c09b6b164ad1a91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4447ddc10cb17829d1862f62e9972fb0 |
| publicationDate | 2022-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-115160429-A |
| titleOfInvention | A kind of preparation method of Tirzepatide |
| abstract | The invention relates to the technical field of polypeptide drug synthesis, and discloses a preparation method of Tirzepatide. The method comprises the following steps: preparing Tirzepatide peptide resin by a solid-phase peptide synthesis method, and obtaining Tirzepatide by cracking the Tirzepatide peptide resin; wherein the method for accessing Aib is: 2-6 peptide fragments containing Aib were used. The process of the invention can significantly reduce the generation of related impurities, and at the same time the yield is guaranteed, and the purification is facilitated. In addition, the synthesis of multiple fragments can be carried out simultaneously, and the synthesis cycle is shortened, which is suitable for large-scale industrial production, and is a Tirzepatide preparation method with wide practical value and application prospect. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-116178523-A |
| priorityDate | 2021-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 130.