| abstract |
The invention discloses a specific topoisomerase inhibitor, an antibody drug conjugate and a preparation method thereof, and belongs to the technical field of medicinal chemistry. The inhibitor compound A or its tautomer, meso, racemate, enantiomer, diastereomer, or mixture thereof, or a pharmaceutically acceptable salt thereof, The structure of compound A is The compound can be further prepared to obtain an antibody-drug conjugate; the antibody-drug conjugate of the present invention has good solubility and druggability, and no precipitation occurs during the coupling process; ADC shows obvious anti-tumor activity in vivo, compared with the control sample Can show significantly stronger antitumor activity. |