| abstract |
The present invention relates to a coumarin compound, a preparation method thereof, and an application against Alzheimer's disease. The coumarin compound has low cytotoxic activity and can selectively inhibit the enzymatic activity of AChE (and BChE). compared) and the enzymatic activities of GSK-3β and BACE1. Therefore, such compounds play an important role in the preparation of drugs for preventing or treating Alzheimer's disease. The general formula of the coumarin compounds is shown in formula I: |