abstract |
The present invention provides a thioamide ALDH 2 agonist or a pharmaceutically acceptable salt or crystal form or solvate thereof, the structure of which is formula I: ; Wherein: n is 1, 2, 3 or 4, m is 1, 2, 3 or 4; Thioamide ALDH 2 agonist of the present invention has good agonist activity; Obtain thioamide with preparation method of the present invention ALDH 2 -like agonists and compositions thereof are useful in medicines for preventing, treating and/or improving various diseases related to ALDH 2 such as drunkenness, essential hypertension, type 2 diabetes and various tumor diseases application. |