| abstract |
The invention belongs to the technical field of chemical synthesis, and in particular relates to a preparation process of iopromide. The process uses 3-amino-5-[(2,3-dihydroxypropyl)carbamoyl)]benzoic acid as a raw material, Iopromide is synthesized through the steps of primary condensation, secondary condensation, chlorination, tertiary condensation, iodination and hydrolysis; the preparation process of iopromide provided by the invention has novel route, low cost, high yield, and can realize green production at the same time, No three wastes discharge, especially suitable for industrialized large-scale production of iopromide. |