| abstract |
The present application provides a gene circuit, an RNA delivery system and applications thereof. Wherein, the gene circuit includes at least one RNA fragment that can inhibit gene expression and/or a targeting tag with targeting function, the gene circuit can be delivered to the host, and enriched in the host's organs and tissues, and self-assembles to form a composite structure , which inhibits gene expression by RNA fragments, thereby treating diseases. The delivery system includes the gene circuit described above and a delivery vehicle capable of delivering the gene circuit to a host's organ tissue enriched. The gene circuit provided by this application has both targeting function and therapeutic function, and can quickly and accurately reach the target organ and target tissue to play a therapeutic role, with high efficiency and good effect; the safety and reliability of the RNA delivery system provided by this application have been recognized by the It has been fully verified that it has good medicine properties, strong versatility, and has excellent economic benefits and application prospects. |