http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115141158-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_066af93d226b9a8b1151cb1bc45bd190 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D257-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D257-04 |
| filingDate | 2021-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28590431cefa4652d18fada6884b2b7b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aca13c3ebb732eca875a49fd3e90cf67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fe3400fcc8dfbad30093f80093d4be6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcc47cfec3eb31084061fa961bf77623 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f500895c56dd8058f4b48628469152c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7855c88ea4882b6a23e48a66f1e30ec3 |
| publicationDate | 2022-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-115141158-A |
| titleOfInvention | A kind of preparation method of valsartan |
| abstract | The invention provides a green and efficient preparation method of valsartan. In water-insoluble secondary or tertiary alcohols, intermediate 1 reacts with sodium azide and zinc halide to obtain valsartan intermediate 2. After the reaction is finished, wash, collect the organic phase and concentrate, add water-insoluble organic solvent, add alkali for saponification, collect the lower layer and add acid, extract with the water-insoluble organic solvent, collect the organic phase for crystallization to obtain valerium with less isomer content and high yield. satan. The invention does not use amine catalysts and does not introduce nitrosamine genotoxic impurities, and the post-treatment reduces the generation of high-nitrogen wastewater, and alcohol can be recovered by distillation, thereby achieving the goal of energy saving and emission reduction. |
| priorityDate | 2021-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.