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classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-107
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-107
filingDate 2022-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba16723826af39adb87ee3daca9a0951
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a93fe53391a1079cee41e2bf8da371c2
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publicationDate 2022-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-115124545-A
titleOfInvention A kind of synthetic method of gonadotropin-releasing hormone receptor antagonist intermediate
abstract The invention relates to a gonadotropin-releasing hormone receptor (GnRH) antagonist intermediate 8-benzyl-3-oxo-1-oxa-8-aza[4,5]decane-4-carboxylic acid A new method for synthesizing ethyl ester belongs to the technical field of synthesis. The specific synthesis method is to add a solvent to the compound represented by the formula (3) to dissolve, then add a base, the compound of the formula (2), and react at a suitable temperature, that is, The product represented by formula (1) can be obtained; the preparation method of the present invention has fewer reaction steps, higher yield than original reports, low cost, simple post-reaction treatment, and high product purity, which can fully meet market demands.
priorityDate 2022-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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