| abstract |
The invention provides a preparation method of 3-hydroxybutanone with high optical purity and application thereof, and belongs to the technical field of preparation of chiral compounds. The preparation method includes separating and purifying 3-hydroxybutanone from a fermentation broth or an aqueous solution or other medium containing 3-hydroxybutanone, maintaining the pH of the material to be weakly acidic, neutral or weakly alkaline during the preparation process, while avoiding a high temperature environment Wherein, the 3-hydroxybutanone in the described fermentation broth or aqueous solution or other medium containing 3-hydroxybutanone is high optical purity AC. The present invention is the first time to study the change of the optical properties of the product during the extraction and purification of biological fermentation 3-hydroxybutanone. S)-AC rules and reasons, through the optimization and adjustment of the extraction process, reduce or avoid the occurrence of the conversion reaction, and obtain the 3-hydroxybutanone product with high optical purity, which is very beneficial to its industrial production. |