| abstract |
The invention discloses a sodium hyaluronate modified drug-carrying MOFs material and a preparation method and application thereof. The sodium hyaluronate is modified on the surface of the MOFs material, and the MOFs pores are loaded with a desired drug. In the present invention, MOFs material is used as an osteoarthritis drug delivery carrier, combined with the surface modification strategy, the long chain of sodium hyaluronate is modified on the surface of the MOFs material through coordination interaction, and the anti-inflammatory drug is further loaded, and a class of products with good water lubrication is obtained. The high-performance drug-loaded MOFs nanocomposites, which are used as joint lubricants, exhibit excellent anti-friction and anti-wear properties and sustained drug release effects. The proposal of this scheme can be used for the programmed construction of biomimetic joint lubricant materials in MOFs drug delivery vehicles Provide theoretical guidance and design basis for lubrication enhancement and drug release. |