| abstract |
The present invention relates to the field of biotechnology, in particular to an antibody or an antigen-binding fragment thereof, and a preparation method and use thereof. The antibody or antigen-binding fragment thereof provided by the present invention can bind to CD147, wherein the binding epitope of the antibody or antigen-binding fragment thereof includes Ala149 of CD147, Asp136 or Asp136 glycosylation modification, Tyr140 or Tyr140 sugar Glycosylation, glycosylation of Gln195 or Gln195, glycosylation of Asp194 or Asp194, glycosylation of Pro104, Asp147 or Asp147, glycosylation of Ser193 or Ser193, glycosylation of Lys191 or Lys191 , Gly192. The antibody or antigen-binding fragment thereof provided by the present invention has a high affinity for MCT1/CD147. |