| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cabefa11a2b65d57dcbbee0a92bcedce |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-146
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0057
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-643 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 |
| filingDate |
2022-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d62ebf11140594c264d67548555fd055
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5de2ddcf1497c8eb5bbe498a27f7cf54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a77c6819bb36a32d34968e922379ef66 |
| publicationDate |
2022-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-115105594-A |
| titleOfInvention |
A kind of MHI-148 chemically modified albumin binding type Sorafenib nano preparation preparation method and application |
| abstract |
The invention relates to a preparation method and application of a MHI-148 chemically modified albumin-binding sorafenib nano-formulation, comprising the following steps: S1, synthesizing MHI-148 chemically modified albumin (BSA-MHI148); S2, BSA -Synthesis of MHI148@SRF nanoparticles; the effect of the albumin-bound sorafenib nanoformulation (BSA-MHI148@SRF) for anti-tumor therapy. The albumin-bound sorafenib nano-formulation (BSA-MHI148@SRF) of the present invention can simultaneously solve the problems of tumor hypoxia and high PD-L1 expression. |
| priorityDate |
2022-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |