| abstract |
The invention relates to a device for constructing a 3D cell co-culture model and its application, belonging to the field of biotechnology. The invention provides a device for constructing a 3D cell co-culture model, comprising a syringe array, a conductive ring, a grounding ring, a high-voltage power supply, a stage, a syringe drive module and a stage drive module. The syringe array is composed of several syringes and is electrically conductive. The ring is set at the needle of the syringe, and the grounding ring is set between the syringe and the carrier. The high-voltage power supply uses the conductive ring as the output end and the grounding ring as the grounding terminal. There are several culture chamber arrays on the carrier, and each culture chamber array is composed of It consists of several large cultivation chambers, each large cultivation chamber is provided with several micro-slots, the micro-slots divide the large cultivation chamber into several small cultivation chambers, the syringe driving module drives the piston rod of the syringe, and the stage driving module drives the stage. The device can simulate the complex structure of human organs and the in vivo microenvironment, and has the advantages of low manufacturing cost and simple manufacturing steps. |