| abstract |
The invention discloses a KCNQ2/3 potassium ion channel selective regulator compound A, which has high opening activity and high selectivity for KCNQ2/3 channels, but has no opening activity for KCNQ1, KCNQ4 and KCNQ5. In view of the fact that the compound A provided by the present invention is a highly active and highly selective KCNQ2/3 channel opener, the present invention also proposes that it can be used in pharmaceutical preparations for the preparation of antiepileptic drugs, analgesics, antidepressants, and for the treatment of ischemic Stroke disease drug application. |