http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115093392-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44e2dd1b3820cbd484519148eb2933d1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D339-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D339-04 |
| filingDate | 2022-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dffad1f4bf4d08d753fca406f75eb556 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e79d51aeddcee0d22450d93c975cba5b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca061595448aae5fb97a98280069f0bb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_001f4d4d4704a69f058d1f737be5db4c |
| publicationDate | 2022-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-115093392-A |
| titleOfInvention | A kind of preparation method of R-lipoic acid |
| abstract | The invention provides a preparation method of R-lipoic acid, the method comprises the following steps: 1,3,7-heptanetriol reacts with 2,2-dimethoxypropane, and the obtained compound INT-1 reacts with brominated Reagent carries out bromination reaction, obtains compound INT-2, then carries out cyanation reaction with cyanating reagent, obtains compound INT-3, then carries out ring-opening and hydrolysis reaction under the effect of vitriol oil, obtains compound INT-4, with (R )-(+)-N, N-dimethyl-1-phenethylamine as basic resolving agent, carries out chiral resolution to compound INT-4, obtains compound INT-5, then reacts with p-toluenesulfonyl chloride , obtain compound INT-6, carry out cyclization reaction with sodium sulfide, sulfur, obtain R-lipoic acid. The invention has mild process conditions, easy-to-obtain raw materials, high optical purity of the chiral intermediate and the final product, is beneficial to the quality control and improvement of the raw material drug of the final product, and is suitable for industrial production. |
| priorityDate | 2022-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 182.