abstract |
The invention discloses the application of a polypeptide in the preparation of a medicine for treating ischemic stroke, and belongs to the technical field of medicine. In the present invention, by establishing an ischemic stroke model of rat middle cerebral artery occlusion/reperfusion (MCAO/R), it is found that the polypeptide of the present application can significantly reduce the neurological deficit of ischemic stroke rats, etc.; In the in vitro cerebral ischemia model of human cerebral microvascular endothelial cells (hCMEC/D3) under the deprivation/reoxygenation and glucose (OGD/R) model, it was found that the polypeptide of the present application can significantly improve the survival rate of cells. |