| abstract |
Described herein are compositions and methods for treating a subject having or at risk of developing Crohn's disease. Using the compositions and methods of the present disclosure, a patient, such as an adult human patient, can be provided with one or more agents that increase the level of expression and/or activity of nucleotide-binding oligomerization domain-containing protein 2 (NOD2). Exemplary agents that can be used in conjunction with the compositions and methods of the present disclosure for this purpose include cells expressing NOD2, such as pluripotent cells. |