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filingDate 2022-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_301fbbb9232d3ff53445e9b35d9128e5
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publicationDate 2022-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-115073924-A
titleOfInvention Composite gel sphere based on physical and chemical cross-linked core-shell structure and preparation method thereof
abstract The invention belongs to the technical field of biological materials, and in particular relates to a composite gel sphere based on a physical and chemical cross-linking core-shell structure and a preparation method thereof. Shaped non-spherical silk fibroin gel particles, the shell of the composite gel sphere is a sodium hyaluronate gel formed by chemical cross-linking, and the quality of the silk fibroin gel in the inner core is greater than that of the sodium hyaluronate gel in the outer shell. quality, the particle size of the composite gel ball is less than or equal to 1000 μm; the gel ball prepared by the invention overcomes the problems of poor single-phase gel mechanical properties, fast degradation rate of hyaluronic acid gel and poor biocompatibility, and is more suitable for Medical injection.
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