| abstract |
The invention provides an olanzapine derivative antigen, an olanzapine antibody and applications thereof, belonging to the technical field of immune detection. The present invention couples the olanzapine derivative hapten with the carrier protein to prepare the complete antigen. After immunizing animals, the olanzapine monoclonal antibody obtained by screening has the ability to recognize olanzapine with high sensitivity, and is resistant to clozapine, Olanzapine, N-O olanzapine, 7-hydroxy olanzapine, and 10-N-glucuronide olanzapine have no cross-reactivity, and their specificity is better than that of existing olanzapine antibodies. Or olanzapine concentration in urine provides protection. |