| abstract |
The invention belongs to the technical field of biomedicine, and in particular relates to a rosin diterpenoid compound and a preparation method and application thereof. Experiments have shown that the rosin diterpenoids have significant anti-proliferation and anti-migration activities on glioma cells, can achieve significant anti-glioma proliferation effects at lower concentrations, and can significantly inhibit tumor cell proliferation. migration, and has a better tumor treatment effect; and the pKa of the rosin diterpenoid compound is in the range of 6-10.5, and has better permeability of the blood-brain barrier, which is beneficial to enter the brain to exert drug effect. |