| abstract |
The invention provides a drug-loaded nanoparticle based on curcumin and cerium oxide and a preparation method thereof. The application comprises using mannose-modified chitosan as a carrier, and coating the curcumin-cerium oxide nanoparticle in the carrier, The drug-loaded nanoparticles are formed, the curcumin nanoparticles are prepared by a desolvation method, and the curcumin-cerium oxide nanoparticles are generated by self-assembly, and then the surface of the curcumin-cerium oxide nanoparticles is combined with mannose modification by electrostatic adsorption. The chitosan is purified by dialysis and collected by freeze-drying. The drug-loaded nanoparticles of the present invention can be administered orally, through the macrophage targeting effect of mannose, the drug can reach the inflammatory site, and the drug can be released by regulating macrophage polarization and anti-oxidation, inhibiting ferroptosis, and increasing the rate of ferroptosis. Beneficial bacteria, inhibit harmful bacteria from balancing the role of intestinal flora, to achieve a more effective treatment of intestinal inflammation. |