| abstract |
The invention discloses a veterinary vaccine delivery system containing Achyranthes polysaccharide and a preparation method thereof. The described delivery system is composed of isopropyl myristate, squalene, Span 80, Tween 80, absolute ethanol and Achyranthes co-modified with sulfated and CpG ODN (CpG oligonucleotide, CpG oligodeoxynucleotide). Polysaccharide composition. Preferably, the mass percentages of each substance are: 60-63% isopropyl myristate, 8-9.5% squalene, 6-7.5% Span 80, 14-15% Tween 80, 7-8% Anhydrous ethanol and 1-2% sulfated Achyranthes co-modified with CpG ODN. The veterinary vaccine delivery system containing Achyranthes polysaccharide of the present invention has good stability, has no obvious toxic and side effects, and can improve the immune response mediated by the antigen. The veterinary vaccine delivery system of the present invention can prepare the vaccine by using magnetic suspension stirring, the process is simple, and the production is easy. |