abstract |
The invention belongs to the technical field of biomedicine, and specifically relates to the application of OTUB1 gene, its detection reagent and inhibitor. The present invention confirms that the expression of OTUB1 gene is elevated in gastric cancer and is associated with low survival rate. By detecting the expression level of the OTUB1 gene in the subject, whether the subject has gastric cancer and the risk of gastric cancer can be determined. The depletion of OTUB1 can inhibit the progression of gastric cancer in vitro and in vivo. It can be seen that the treatment of gastric cancer with OTUB1 gene as a target has good feasibility and popularization. |