http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115057893-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_489aa2cd1ae60fe92ef599b7516b721d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F17-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-555 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3357d719dcb384b6aa7b441343f09d13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8facd5e4de8e9834ae226b42d051a031 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1e75e02a35303496be44526091fb18e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23cd681f6b6c685d67c7dc9e5b3ff21d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6882f52dc39eb3105c80a64b5a649ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66f1987ff783f042c79acff1076a37d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71b089c69b4a9b7d31262f9624fd34aa |
| publicationDate | 2022-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-115057893-A |
| titleOfInvention | A sandwich configuration of organometallic iridium complex targeting mitochondria and its preparation method and application |
| abstract | The invention relates to a metal iridium complex, belonging to the field of chemical pharmacy, in particular to an organometallic iridium complex targeting mitochondria in a sandwich configuration, a preparation method and an application thereof. Its structural formula provided by the invention is shown in formula (I)～(III): The sandwich configuration metal iridium complex provided by the invention can be located in the mitochondria, induce its functional disorder to lead to the apoptosis of cancer cells, has high anti-cancer activity, good selectivity, and is not easy to produce drug resistance; the series of complexes It has good anticancer activity, in vitro anticancer activity is better than cisplatin, and has good stability, which provides a new strategy and experimental basis for the development and research of anticancer metal complexes. The preparation method provided by the invention has high synthesis efficiency, and the prepared target complex can be accumulated in mitochondria in cells to induce early apoptosis of cells. |
| priorityDate | 2022-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.