| abstract |
The invention discloses a nitrogen-containing heterocyclic compound, an intermediate, a preparation method, a composition and an application. The nitrogen-containing heterocyclic compound of the present invention is shown in formula I. The compound has high inhibitory activity on ErbB2 tyrosine kinase, and has good inhibitory activity on human breast cancer cells BT-474 and human gastric cancer cells NCI-N87 with high ErbB2 expression, while the inhibitory activity on EGFR kinase is relatively weak , that is, a small molecule inhibitor with better selectivity for ErbB2 target, so its safety is high, and it can effectively increase the safety window during drug administration. |