| abstract |
The invention discloses an intermediate of an optically active beta-hydroxy ester compound. The present invention provides an intermediate compound (4-1) of an optically active β-hydroxy ester compound. The intermediate is used in a preparation method of an optically active β-hydroxyester compound, and the preparation method comprises the following steps: in water, under the action of penicillin acylase, hydrolyze the compound (4-1) reaction, you can. The intermediate compound (4-1) of the present invention is matched with a specific hydrolase. In the above preparation method, when the amino protecting group is removed, the methyl group in the methyl carboxylate is not affected in any way, and can be directly carried out. The subsequent cyclization reaction has short steps, simple operation and low cost, and is more suitable for industrial production. |