http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115043807-A

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filingDate 2022-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34ad040a759b9120d5826041c39ca878
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publicationDate 2022-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-115043807-A
titleOfInvention Monofluorinated 4H-pyran compound and its synthesis method
abstract The invention belongs to the technical field of organic compound synthesis and application, and provides a monofluorinated 4H-pyran compound and a synthesis method thereof. Ethyl ester II-b or 5,5-dimethyl-1,3-cyclohexanedione II-c is reacted in a base and a solvent to synthesize a series of monofluorinated 4H-pyran compounds 3 under the same reaction conditions The synthesis method of the invention is simple and feasible, does not need transition metal catalysis, the raw materials are cheap and easy to obtain, the substrate is widely applicable, and the yield is high. The synthesis method of the invention does not need transition metal catalysis, the raw materials are cheap and easily available, the reaction conditions are mild, the operation is simple and feasible, the yield is high, and the functional group tolerance is good. The construction of this method enriches the synthesis methods of fluorinated tetrahydropyran compounds, and lays a synthetic foundation for the application of the highly active fluorinated 4H-pyran derivatives in the fields of medicine and materials.
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Total number of triples: 29.