http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115038970-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8f5dfc0eed1db83b989cce292d784356 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1037 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2020-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9308fb80a7aad11c5844718e4bd4fe57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a43cbc2a83af07eeb4aba3edb7d43ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e48a0840108df607e1e5bd383e47e75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_957f703ebaa5c70fb9ae3f6538646500 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05ede57a9cff579d3d2bba75cb8e3d12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_295844edfd8f1c8fbc09979f68f0b2a4 |
| publicationDate | 2022-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-115038970-A |
| titleOfInvention | Phage cyclization assay |
| abstract | The present invention relates to a method for determining the degree of cyclization of a peptide ligand displayed on a genetic display system, wherein the peptide ligand comprises a polypeptide covalently linked to a molecular scaffold at two or more amino acid residues , which comprises the steps of: exposing a polypeptide displayed on the genetic display system to the molecular scaffold, wherein the polypeptide comprises two or more peptide-reactive groups at the two or more amino acid residues, It forms a covalent bond with a molecular scaffold at two or more scaffold-reactive groups to obtain the peptide ligand; removes the unreacted molecular scaffold from the genetic display system; displays the genetic display system on the of the peptide ligand is exposed to a first probe, wherein the first probe binds to a first unconjugated reactive group on the peptide ligand; and measuring the first unconjugated group on the peptide ligand reactive groups. |
| priorityDate | 2019-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 397.