| abstract |
The invention discloses a PROTAC compound for targeted degradation of Cyclophilin A and a preparation method and application thereof. The structural formula of the PROTAC compound is shown in formula I. The compounds of formula I provided by the present invention can be used for the prevention and/or treatment of CypA-mediated diseases, such as CypA-mediated inflammation, autoimmune diseases and/or tumors. The present invention also provides a pharmaceutical composition comprising the compound of formula I as an active ingredient and at least one pharmaceutically acceptable carrier, excipient and/or diluent. The PROTAC compound provided by the present invention can degrade CypA protein in a targeted manner, so it can be used to prepare medicines for treating inflammation, autoimmune disease, tumor and other related diseases; the compound represented by the formula I of the present invention is effective for virus-induced pneumonia, rheumatoid joint disease, etc. Inflammation and lung cancer cell migration and infiltration have obvious inhibitory function. |