| abstract |
The invention discloses a glycosylated polylysine-polyethylene glycol hydrogel and a preparation method and application thereof, belonging to the field of biomedical materials. The hydrogel is formed by rapidly curing glycosylated polylysine and polyethylene glycol derivatives at room temperature, wherein glycosylated polylysine is selected from formula (1) or (2), polyethylene glycol The derivatives are selected from formulae (3), (4), (5) and (6). The glycosylated polylysine-polyethylene glycol hydrogel of the present invention has excellent dual functions of arterial hemostasis and biological activity to promote healing, has important clinical transformation potential as a wound dressing, and solves the problem of existing arterial hemostasis hydrogel dressings The problems of uncontrollable anti-vascular burst pressure, poor arterial hemostasis and lack of biological activity to promote wound healing. |