| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_900294f396b66b4694648daa18c8a4c8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N27-416
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N27-3277
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6825
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-682
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6806
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B22F9-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N27-3278
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B22F1-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B22F9-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B22F1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-327
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-416
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6806
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6825
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-682 |
| filingDate |
2022-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86de5ec145e3e9bd47b5defacd1ace51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b25004108457c92e25133f7e360ba2d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a1ff0434211fcb1d87ad1bcc1663254 |
| publicationDate |
2022-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-115011667-A |
| titleOfInvention |
Construction method and application of an efficient DNA walker for rapid and sensitive detection of DNA methylation |
| abstract |
The invention discloses a construction method and application of a high-efficiency DNA walker for rapid and sensitive detection of DNA methylation, including: preparing a bimetallic MOF material; designing an efficient DNA walker; performing nucleic acid functionalization on the bimetallic MOF material; An electrochemical sensing interface was constructed to detect the methylation status of DNA. The high-efficiency DNA walker for fast and sensitive detection of DNA methylation in the present invention utilizes the strand displacement reaction mediated by DNA strand transfer and combines the high catalytic performance of bimetallic MOF materials to construct a fast and sensitive electrochemical DNA methylation The sensing platform can identify DNA with different degrees of methylation, which is of great significance for the early diagnosis of related clinical diseases and the study of genetic information mechanism. |
| priorityDate |
2022-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |