http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115011550-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_206bb30ecf736a6c212576cd5309e861 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-237 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2531-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-067 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate | 2022-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7461a16d5ede4a85a11f2639dc059bd8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_159bf66d06f73849a4cfa132753a8b7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8909c9062a23131083cf3c8e863a10f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b616dc6ce108d0499848d22092ae731 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e05e47e6e63d24c1879575825a2638ed |
| publicationDate | 2022-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-115011550-A |
| titleOfInvention | A kind of induction medium and method for inducing differentiation and maturation of hepatocytes under suspension culture conditions |
| abstract | The invention discloses an induction medium and a method for inducing differentiation and maturation of hepatocytes under suspension culture conditions, and relates to the technical field of cell culture. The present invention is to add Notch signal pathway blocker, TGF-β signal pathway blocker, dexamethasone and oncostatin M to the hepatocyte culture medium under the condition of suspension culture, and through the medium, the hepatic progenitor is treated with The cells are induced to differentiate, and functionally mature hepatocytes can be obtained stably and efficiently. The invention establishes a stable and efficient large-scale method for preparing functional mature hepatocytes, provides a reliable cell source for clinical bioartificial liver and hepatocyte transplantation therapy, and provides application of hepatocytes in the fields of liver disease mechanism research, drug research and development, etc. Open up new ideas and ways. |
| priorityDate | 2022-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 88.