| abstract |
The invention discloses a catalase-inspired nanocomposite hydrogel and a preparation method and application thereof. This method prepares manganese cobalt oxide nanoparticles modified by amino compounds, and uses natural macromolecules as the main matrix to construct nanocomposite hydrogels, which can stably form gels under physiological conditions, so as to achieve uniform encapsulation and friendly transport of stem cells. the goal of. Using the breaking and reorganization of reversible bonds, the hydrogel can quickly achieve mechanical recovery and network self-healing, so as to better adapt to the dynamic mechanical microenvironment at the joint. The hydrogel three-dimensional nanoscale channel is beneficial to the metabolism of stem cells, and can provide a favorable microenvironment for the adhesion, communication and proliferation of stem cells. The hydrogel can catalyze the decomposition of endogenous H 2 O 2 to generate O 2 , overcome the damage to cells caused by hypoxia and high concentration of ROS, and improve the pathological environment of RA with hypoxia and high ROS concentration. Stem cell viability. |