http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115010665-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1b4df81c5dda672e3b1723888b239760 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-24 |
| filingDate | 2022-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0aebeea241e42f769bc533b5dd0d354 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b209458bb0d1935ce0f373cb2ba9ef62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35f1f8473b32cd627f2af284da49235e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_491a1815e024f814c072a493ce9793eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0a1e020689a19f10e9bd376438d8c75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8925f17b5acc9184b740978ab093b4cd |
| publicationDate | 2022-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-115010665-A |
| titleOfInvention | A kind of synthetic method of terbutaline sulfate impurity B |
| abstract | The invention belongs to the technical field of medicinal chemistry, and in particular relates to a method for synthesizing impurity B of terbutaline sulfate. Using p-2-bromo-3', 5'-dihydroxyacetophenone as a raw material, terbutaline sulfate impurity B is prepared through 5 steps of esterification reaction, substitution reaction, cyclization reaction, hydrolysis reaction and reduction reaction. The synthesis method of the invention has the advantages of simple reaction process, readily available raw materials, and a total yield of more than 50%, which contributes to strictly controlling the content of impurity B of terbutaline sulfate by using an external standard method; the reaction conditions are mild, and the product purity is High, suitable for drug quality research, to provide assurance for improving the quality of terbutaline sulfate APIs. |
| priorityDate | 2022-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.