| abstract |
The invention discloses a preparation method of an o-iodophenyl compound, which uses an iodobenzene compound and an amide compound as raw materials, and reacts to obtain an o-iodophenyl compound in the presence of sodium hydride or n-butyllithium and a solvent. As organic chemistry penetrates into all aspects of life, it is crucial to explore green, environmentally friendly, convenient and efficient synthetic methods with high atom utilization in drug synthesis process research and development or other industrial manufacturing. Compounds containing C-N bonds not only exist widely in nature, but also play an irreplaceable role in the field of biomedicine. The invention introduces a new method for efficiently constructing C-N bonds by using o-diiodobenzene as a precursor without requiring metal catalysts, expensive and special ligands, high temperature, high pressure and other conditions. |