| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c13f0402219c2a116474be2bfca70c5 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-36 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0601
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0083
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-99038 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate |
2022-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce7d46924eb602b9d2167c44c16c2f20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d3d47c7553bbf9cb780c321b8bba8e6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43ca11643e083a09e4ae2b6df6039a17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22226593db0745763e6cc5eaff61c1da
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bcdce21414ff3b428ca2a8824c09229 |
| publicationDate |
2022-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-115006519-A |
| titleOfInvention |
Use of cholesterol-25-hydroxylase and its enzymatic products in the preparation of anti-Bombyx mori nuclear polyhedrosis virus drugs |
| abstract |
The invention belongs to the field of agricultural biology, and relates to the use of Bombyx mori cholesterol-25-hydroxylase and its enzymatic product in preparing an anti-Bombyx mori nuclear polyhedrosis virus drug. In the present invention, the Bombyx mori nuclear polyhedrosis virus (BmNPV) is used to infect cells and silkworm larvae to cause the expression of cholesterol-25-hydroxylase (BmCH25H) to be up-regulated, and the up-regulated BmCH25H can inhibit the replication of BmNPV. At the same time, the enzymatic product of BmCH25H is found. 25-hydroxycholesterol (25HC) also has inhibitory effect on BmNPV infection. The present invention proves for the first time that overexpression of BmCH25H and 25HC can inhibit BmNPV infection through in vitro and in vivo experiments. |
| priorityDate |
2022-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |