| abstract |
The invention discloses an anti-EV71 virus antibody and a preparation method and application thereof. The amino acid sequences of CDR1, CDR2 and CDR3 of the heavy chain of the anti-EV71 virus antibody respectively include those shown in SEQ ID NO.1, SEQ ID NO.2 and SEQ ID NO.3 The amino acid sequences of CDR1, CDR2 and CDR3 of the light chain of the antibody respectively include the sequences shown in SEQ ID NO. 4, SEQ ID NO. 5 and SEQ ID NO. 6. The anti-EV71 virus antibody of the present invention can recognize the spatial epitope of the EV71-VP1 protein, but does not recognize the linear epitope, and has a good neutralizing effect, which is of great significance for further research on the disease mechanism of EV71 virus infection and formulation of prevention and control strategies. |