http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114984251-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55f24cf64da16f340418470f535adb50 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-221 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-223 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-22 |
| filingDate | 2022-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c5867d1b2868493b0ffc06995625978 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca710cac5d5a5b5dc5fa7a836fa211ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f70f65a26cfd72c93d2275245f67b6f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_daf43443b51600d1f145473bfe5fbf2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5a94a6454fb75f41bc731f47ebc7740 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ba464e29d71ee4334d04f566b03a760 |
| publicationDate | 2022-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114984251-A |
| titleOfInvention | A kind of preparation method and application of ultrasonic targeting microbubble carrying bifunctional ligand |
| abstract | The invention discloses a preparation method and application of ultrasonic targeting microbubble carrying dual functional ligands. The preparation method of ultrasonic targeting microbubble carrying dual functional ligands of the present invention comprises the following steps: (1) different doses After the biotin-fluorescence double-labeled ICAM-1+HIF-1α and IL-8+HIF-1α antibodies were targeted to the microvesicles, the binding efficiency of the antibodies and the microvesicles was detected by flow cytometry and observed by a fluorescence microscope; ( 2) Preparation of ultrasound-targeted microbubbles carrying bifunctional ligands. The present invention provides a method for preparing ultrasound-targeted microbubbles carrying dual-functional ligands, and utilizes the targeted microbubbles traced by inflammatory factors to inhibit the HIF pathway to make plaques more stable. |
| priorityDate | 2022-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.