| abstract |
The invention belongs to the technical field of pharmaceutical preparations, and relates to a temperature-sensitive instant gel system and its preparation and application. The temperature-sensitive instant gel system is composed of poloxamer, vitamin E, lactic acid, triethanolamine and It is composed of water or buffer solution, its phase transition temperature is between 28 and 37°C, and it solidifies into a semi-solid gel within 20 to 150 seconds after the ambient temperature is rapidly raised from room temperature to body temperature, and the instant gel of the present invention enters the cavity. The gel form formed on the mucosal folds after deep penetration can prolong the contact time between the drug and the mucosa, and increase the chance of the drug permeating into the mucosa or interacting with pathogens on the surface of the cavity. It is suitable for a variety of mucosal routes, and can be further prepared for vaginal administration. drug, rectal or nasal preparations. |