http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114966043-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c13f0402219c2a116474be2bfca70c5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-8675 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-689 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-86 |
| filingDate | 2022-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c199c94c8f05d546faa1a03666ae683 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9dc923278d522cb6e4797f88d6140360 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33bcd5d817bbdf16cef74080eb75c5c5 |
| publicationDate | 2022-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-114966043-A |
| titleOfInvention | Application of GPLD1 protein in predicting the effect of repeated superovulation response in cynomolgus monkeys |
| abstract | The invention belongs to the technical field of superovulation. Through proteomic analysis, the expression level of GPLD1 on the first day of superovulation in the successful group gradually decreased, and the magnitude was not obvious. In the failure group, the level of GPLD1 on the first day of the second superovulation decreased Compared with the first day of the first superovulation, it is speculated that the transition from success to failure of superovulation in cynomolgus monkeys is related to it. Mammalian GPLD1 glycosylated phosphatidylinositol-specific phospholipase D1 is involved in the GPI-anchored biosynthetic pathway and is involved in various cellular processes including cell differentiation, adhesion and survival by releasing membrane-bound GPI-anchored proteins from the cell surface Play a key role; in the repeated superovulation procedure of cynomolgus monkeys, the plasma GPLD1 level on the first day of this superovulation decreased (more than twice) compared with the level on the first day of the previous superovulation, which may indicate the failure of this superovulation. The changes of GPLD1 levels in plasma on the first day of sub-superovulation can screen out repeatable superovulation individuals before superovulation, achieve high superovulation efficiency, and greatly save the time and economic cost of superovulation in cynomolgus monkeys. |
| priorityDate | 2022-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.