| abstract |
The invention discloses a reagent R1, a reagent kit and an application for detecting valproic acid by a latex-enhanced immune turbidimetric method. The reagent R1 includes a protein-bound valproic acid dissociating agent, and the dissociating agent includes 1) acetylsalicylic acid, or 2) cimetidine and erythromycin. The kit of the invention can more accurately detect the drug content of total valproic acid in free state in plasma or serum, and compared with commercial kits, the determination value is more similar to HPLC-MS/MS, and can be quickly applied to conventional automatic biochemical instruments In the detection of , on the basis of convenient detection, it provides more accurate reference values for clinical practice. |