| abstract |
The invention belongs to the field of biotechnology, and in particular relates to an ERα positive breast cancer molecular marker and its application. The molecular markers include any one of the following or a combination thereof: 1) PSMD14 gene, which has the DNA sequence shown in SEQ ID NO. 1; 2) the expression product of PSMD14 gene. The present invention proves that the expression of PSMD14 is increased in breast cancer in both clinical samples and experimental studies, and is only related to poor survival in patients with endoscopic breast cancer, and regulating the activity or gene expression level of PSMD14 will be the treatment of breast cancer. an attractive strategy for cancer. |